Super-Resolution Displacement Spectroscopic Sensing over a Surface “Rainbow”

Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy, sensing, medical imaging. For these applications, miniaturized spectrometers are desirable to the on-chip analysis spectral information. In particular, for imaging-based spectroscopic sensing mechanisms, key challenge is determine spatial-shift information accurately (i.e., spatial displacement introduced by wavelength shift or biological chemical surface binding), which similar presented super-resolution Here, we report a unique “rainbow” trapping metasurface sensors. Combined image processing, low-setting 4× optical microscope system resolves resonant position within 35 nm on plasmonic rainbow tiny area as small 0.002 mm2. This feature efficiently coupled resonances reveals platform resolution 0.032 shift. Using this imaging system, demonstrate biosensing 1.92 × 109 exosomes∙mL−1 A549-derived exosomes distinguish between patient samples healthy controls using exosomal epidermal growth factor receptor (EGFR) expression values, thereby demonstrating personalized accurate bio/chemical applications.